Ox40 Polyclonal Antibody, 100ul[BT-AP06724] Culture Tubes Mutations in this gene are

Mutations in this gene are associated with venous thrombosis

Contains two independent C-terminal transactivation domains| NTAD and CTAD| which function synergistically

are found to form a gene cluster on chromosome 3p

A related pseudogene has been identified on chromosome 13

Ox40 Polyclonal Antibody, 100ul[BT-AP06724] Culture Tubes Mutations in this gene areThe protein encoded by TNFRSF4 (TNF receptor superfamily member 4) is a member of the TNF receptor superfamily. This receptor has been shown to activate NF kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1 BCL2 XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+