Beclin-1 mouse Monoclonal Antibody(5C2), 100ul Peripheral Blood Separation Tube Contains 2 SAM (sterile alpha

Contains 2 SAM (sterile alpha motif) domains

Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member

Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner

The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor

Beclin-1 mouse Monoclonal Antibody(5C2), 100ul Peripheral Blood Separation Tube Contains 2 SAM (sterile alphaThis gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol 3 kinase (PI3K) complex which mediates vesicle trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.