IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath Expressed predominantly in the brain

Expressed predominantly in the brain

Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent

The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain

the gene for the other resides on chromosome 16

IP3R-I Polyclonal Antibody, 100ul[BT-AP04603] Dry Bath Expressed predominantly in the brainITPR1 (inositol 1,4,5 trisphosphate receptor type 1) encodes an intracellular receptor for inositol 1,4,5 trisphosphate. Upon stimulation by inositol 1,4,5 trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for ITPR1.