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PDK2 Polyclonal Antibody, 50ul Multi-Layer Cell Culture System Found in a pre-mRNA exonic

SKU: 80316684603

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PDK2 Polyclonal Antibody, 50ul Multi-Layer Cell Culture System Found in a pre-mRNA exonicPDK2 encodes a member of the pyruvate dehydrogenase kinase family. Pyruvate dehydrogenase kinase 2 phosphorylates pyruvate dehydrogenase, down regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of PDK2 may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PDK2.

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Description

Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70

It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types

which contributes to Alzheimer's disease

The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin

PDK2 Polyclonal Antibody, 50ul Multi-Layer Cell Culture System Found in a pre-mRNA exonicPDK2 encodes a member of the pyruvate dehydrogenase kinase family. Pyruvate dehydrogenase kinase 2 phosphorylates pyruvate dehydrogenase, down regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of PDK2 may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for PDK2.

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