Malic enzyme 1 Polyclonal Antibody, 100ul Centrifugal Filter Mutation in the promoter of

Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers

The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum

Transcript variants for this gene have been described

and is imprinted and expressed from the paternal allele

Malic enzyme 1 Polyclonal Antibody, 100ul Centrifugal Filter Mutation in the promoter ofME1 encodes a cytosolic, NADP dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for ME1 is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.