PBIP1 Rabbit Polyclonal Antibody, 50ul Shaker&Mixing Defects in this gene appear

Defects in this gene appear to be a cause of various types of leukemia or lymphoma

Among its related pathways are Metabolism and Sphingolipid signaling pathway

The encoded protein also promotes transcription at the c-fos gene

and it is present in a cluster with other family members on chromosome 22

PBIP1 Rabbit Polyclonal Antibody, 50ul Shaker&Mixing Defects in this gene appearThe protein encoded by this gene interacts with the PBX1 homeodomain protein inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein which is primarily cytosolic but can shuttle to the nucleus also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer brain tumors and lung cancer. Several transcript variants encoding different isoforms have been found for