Rb(Phospho Ser780) Polyclonal Antibody, 20ul Dialysis The SH2-binding sites putatively bind

The SH2-binding sites putatively bind CRK| NCK and ABL SH2 domains

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Allelic variants of this gene exist that confer susceptibility to diabetes mellitus

Mitogen-activated protein kinase kinase kinase 7 encoded by MAP3K7 is a member of the serine/threonine protein kinase family

Rb(Phospho Ser780) Polyclonal Antibody, 20ul Dialysis The SH2-binding sites putatively bindThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.