SPAK(Phospho Ser323) Polyclonal Antibody, 50ul 3D Culture Contains 3 TPR repeats

Contains 3 TPR repeats

Mutations in this gene cause autosomal dominant severe congenital neutropenia

The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis

designated the Sec insertion sequence (SECIS) element

SPAK(Phospho Ser323) Polyclonal Antibody, 50ul 3D Culture Contains 3 TPR repeatsThis gene encodes a serine threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation chloride coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the