Arkadia Polyclonal Antibody, 20ul Gene Editing Polymorphisms in this protein appear

Polymorphisms in this protein appear to be tissue specific and influence protease targeting

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Arkadia Polyclonal Antibody, 20ul Gene Editing Polymorphisms in this protein appearThe protein encoded by RNF111 (ring finger protein 111) is a nuclear RING domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) beta NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF beta target gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the