GDF11 Rabbit Polyclonal Antibody, 50ul Cell fragmentation and collection disease:Defects in GRN are the

disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD)

The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB)| both anchored in the membrane

This protein also interacts with and is acetylated by MCM3AP| a chromatin-associated acetyltransferase

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors

GDF11 Rabbit Polyclonal Antibody, 50ul Cell fragmentation and collection disease:Defects in GRN are theThis gene encodes a secreted ligand of the TGF beta (transforming growth factor beta) superfamily of proteins. Ligands of this family bind various TGF beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide linked homodimer. This protein plays a role in the development of the nervous and