Rb Polyclonal Antibody, 100ul[BT-AP07693] sgRNA Library Construction More than a dozen pseudogenes

More than a dozen pseudogenes of this gene have been identified

and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences

it is required for maximal ATPase activity of BRG1

or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL

Rb Polyclonal Antibody, 100ul[BT-AP07693] sgRNA Library Construction More than a dozen pseudogenesThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.