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TGR5 Polyclonal Antibody, 20ul Cytokines Multiple alternatively spliced transcript variants

SKU: 94177322991

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TGR5 Polyclonal Antibody, 20ul Cytokines Multiple alternatively spliced transcript variantsGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.

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Description

Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene

this protein may play a role in metal homeostasis

and ovarian tumors

inducing its proteasomal degradation

TGR5 Polyclonal Antibody, 20ul Cytokines Multiple alternatively spliced transcript variantsGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.

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