Crk-L(Phospho Tyr207) Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection It is subject to negative-feedback

It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family

The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein

Crk-L(Phospho Tyr207) Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection It is subject to negative-feedbackThis gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS dependent fashion. It is a substrate of the BCR ABL tyrosine kinase, plays a role in fibroblast transformation by BCR ABL, and may be oncogenic.