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Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis

This gene encodes a member of the dual specificity protein kinase family

The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs

GTBP Monoclonal Antibody, 100ul[BT-MCA0646] Biochemical Reagents Bring versatility to your labThis gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP