Pin1 Polyclonal Antibody, 20ul Vortex Mixer PDZ and LIM domain 1

PDZ and LIM domain 1 contains two protein interacting domains

In vitro studies have shown menin is localized to the nucleus

The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform

a homodimer

Pin1 Polyclonal Antibody, 20ul Vortex Mixer PDZ and LIM domain 1Peptidyl prolyl cis trans isomerases (PPIases) catalyze the cis trans isomerization of peptidyl prolyl peptide bonds. PIN1 (peptidylprolyl cis trans isomerase, NIMA interacting 1) encodes one of the PPIases, which specifically binds to phosphorylated ser thr pro motifs to catalytically regulate the post phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved