HAUSP Monoclonal Antibody, 50ul[BT-MCA0663] Gene Editing Five isocitrate dehydrogenases have been

Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases

and a carboxy-terminal non-collagenous domain

This gene has a mouse ortholog

Consistent with the expression of the encoded protein in photoreceptor cells of the retina

HAUSP Monoclonal Antibody, 50ul[BT-MCA0663] Gene Editing Five isocitrate dehydrogenases have beenThe protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in