TRI69 Rabbit Polyclonal Antibody, 100ul Enzyme Activity Assays Mutations in and decreased expression

Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis

an autosomal dominant multisystemic vascular dysplasia

a mitogen and a hormone

which modifies various nuclear proteins by poly(ADP-ribosyl)ation

TRI69 Rabbit Polyclonal Antibody, 100ul Enzyme Activity Assays Mutations in and decreased expressionThis gene encodes a member of the RING B box coiled coil (RBCC) family and encodes a protein with an N terminal RING finger motif a PRY domain and a C terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and when overexpressed induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.