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Mutations in NRL have been associated with retinitis pigmentosa and retinal degenerative diseases

and two most abundant spliced variants encode the somatic form and the testicular form

Alternatively spliced transcript variants encoding the same protein have been found

CD6 Polyclonal Antibody, 100ul[BT-AP02476] Endonucleases & Exonucleases unleash your potential and takeKRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate sized filaments in the cytoplasm of epithelial cells. The product of KRT8 typically dimerizes with keratin 18 to form an intermediate filament in simple single layered epithelial cells. Keratin 8 plays a role in maintaining cellular structural integrity and also functions in signal transduction