AY 77 Size:10mg solid 5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide

5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide

InChiKey: KRIKILRRJCIWNB-UHFFFAOYSA-N

15-tetrahydroxy-6'-[(1Z)-2-hydroxy-1-propen-1-yl]-5'

A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist

AY 77 Size:10mg solid 5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamideAY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+ over ERK1 2 signaling (EC50 values are 40 nM for Ca2+ release versus 2 M for ERK1 2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cells in vitro. Product information CAS Number: 1835734 92 3 Molecular Weight: 404. 50 Formula: C21H32N4O4 Synonym: AY77 AY 77 Isox Cha Chg NH2 Chemical Name: N ((S) 1 (((S) 2 amino 1 cyclohexyl 2