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A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 60042 NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1

A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 60042 NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1

Name: A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 60042 NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1
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SKU: 21540508418
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SKU: 21540508418

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A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 60042 NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1A01, CAS No. 1007647 73 5, is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3. 7 nM. It attenuates Smurf1 mediated Smad 1 5 degradation and enhances BMP signaling. It also potentiates BMP 2 induced osteoblastic activity in C2C12 myoblasts and MC3T3 E1 osteoblast precursor cells. Product information CAS Number: 1007647 73 5 Molecular Weight: 512. 93 Formula: C22H20ClF3N4O3S Chemical Name: (4 ((4 chloro 3

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Description

NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1

3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1

It has general >100-fold selectivity against other bromodomains including BRPF2

HuH7 and JHH7 cells

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