AZD1981 hlorophen 212141-51-0 (Vatalanib hydrochloride)

212141-51-0 (Vatalanib hydrochloride)

sometimes abbreviated to neohesperidin DC or simply NHDC

potent and selective prostanoid EP4 receptor antagonist

InChi: InChI=1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7

AZD1981 hlorophen 212141-51-0 (Vatalanib hydrochloride)AZD1981is an orally available selective CRTH or DP2 antagonist currently in clinical development for asthma. AZD1981 blocks functional responses in eosinophils, Th2 cells and basophils. AZD1981 displaced radio labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8. 4). Binding was reversible, non competitive and highly selective against a panel of more than 340 other enzymes and receptors, including DP1 (>1000 fold selective). AZD1981