Talnetant Hydrochloride Size:Solid 2 mg InChiKey: DHYXNIKICPUXJI-UHFFFAOYSA-N

InChiKey: DHYXNIKICPUXJI-UHFFFAOYSA-N

28(5):459-66

Nrf2 translocates to the nucleus

The induction of Cryj1-dependent IgE synthesis mediated by SN-4 is suppressed in a concentration-dependent manner by Suplatast tosilate (1 and 10 µg/ml) in autologous B cells

Talnetant Hydrochloride Size:Solid 2 mg InChiKey: DHYXNIKICPUXJI-UHFFFAOYSA-NTalnetant (SB 223412) is a potent and selective NK3 receptor antagonist (ki=1. 4 nM, hNK 3 CHO); 100 fold selective for the hNK 3 versus hNK 2 receptor, with no affinity for the hNK 1 at concentrations up to 100 uM. IC50 Value: 1. 4 nM (hNK 3 CHO binding Ki) Target: NK3 receptorin vitro: In vitro studies demonstrated that 53 is a potent functional antagonist of the hNK 3 receptor (reversal of senktide induced contractions in rabbit isolated iris