SB505124 - CAS# 694433-59-5 0022 hydrochloride is an oral bioavailabile

hydrochloride is an oral bioavailabile TGF-beta signaling agonist

Cell outgrowth from explants dissected from eyes to which SB505124 is applied during GFS is robust while outgrowth is poor from those treated with MMC

Mohammed A

(2009) Nature

SB505124 - CAS# 694433-59-5 0022 hydrochloride is an oral bioavailabileSB505124, CAS No. 694433 59 5, is a selective inhibitor of transforming growth factor type I receptor (ALK5, ALK4 and ALK7) with potential anticancer activity. SB505124 selectively inhibits signaling from TGF and activin; does not inhibit other ALK family members. SB 505124 selectively and concentration dependently inhibits ALK4 , ALK5 , and ALK 7 dependent activation of downstream cytoplasmic signal transducers, Smad2 and Smad3, and of TGF beta