AUY-922 - CAS# 747412-49-3 Catalog No.:M6487-10 NVP-TAE684 markedly reduces cell survival

NVP-TAE684 markedly reduces cell survival in both sensitive H3122 and H3122 CR cells

This Wnt-dependent culture system should provide a platform for complete replacement of growth factors with chemical compounds

BI-2536 treatment ranging from 10 nM to 100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes

1714146-59-4

AUY-922 - CAS# 747412-49-3 Catalog No.:M6487-10 NVP-TAE684 markedly reduces cell survivalAUY 922, also known as Luminespib, NVP AUY922, VER52296, CAS No. 747412 49 3, is a derivative of 4, 5 diarylisoxazole and a third generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY 922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock