Siramesine 779 (2003) Mol Cancer Ther

(2003) Mol Cancer Ther

MDV-3100 shows dose-independent pharmacokinetics at intravenous and oral doses of 0

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Aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety

Siramesine 779 (2003) Mol Cancer TherSiramesine, also known as Lu 28 179, is a potent sigma 2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress. Product information CAS Number: 147817 50 3 Molecular Weight: 454. 58 Formula: C30H31FN2O Chemical Name: 1' {4 [1 (4 fluorophenyl)