SB525334 - CAS# 356559-20-1 60295 FH535 suppresses the proliferation and

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SB525334 - CAS# 356559-20-1 60295 FH535 suppresses the proliferation andSB525334, CAS No. 356559 20 1, is a potent and selective inhibitor of the transforming growth factor beta1 (TGF beta1) receptor, activin receptor like kinase (ALK5). SB525334 inhibited ALK5 kinase activity with an IC(50) of 14. 3 nM and was approximately 4 fold less potent as an inhibitor of ALK4 (IC(50) = 58. 5 nM). SB 525334 was inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC(50) > 10, 000 nM). In cell based assays, SB 525334 (1 microM) blocked

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