SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-2S Molecular Weight: 412

Molecular Weight: 412

Chemical Name: potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate

GDC-0068 was used at 5-10 µM final concentration in vitro and in cellular assays

OSI-027 shows robust antitumor activity in several different human xenograft models representing various histologies

SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-2S Molecular Weight: 412SR9009, CAS No. 1379686 30 2, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~670 nM and REV ERB with EC50 ~800 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9009 alters circadian behavior and the circadian pattern of core clock