RG108 - DNA Methyltransferase Inhibitor. CAS# 48208-26-0 istone Methyltransferase PubMed PMID: 25775813

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RG108 - DNA Methyltransferase Inhibitor. CAS# 48208-26-0 istone Methyltransferase PubMed PMID: 25775813RG108, CAS No. 48208 26 0, is a potent, selective and cell permeable inhibitor of DNA methyltransferase. Unlike 5 azaC, RG108 is not a nucleoside and therefore does not modify DNA. It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM. It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Treatment with RG108 results in the demethylation of genomic DNA and can reactivate

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