JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 PubMed Central PMCID: PMC4752338

PubMed Central PMCID: PMC4752338

thus attenuating phosphorylation of the Aurora substrate H3S10

Formula: C27H32N8O2

The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1

JNK-IN-8 - CAS# 1410880-22-6 Catalog No.:M6416-10 PubMed Central PMCID: PMC4752338JNK IN 8, also known as JNK Inhibitor XVI, CAS No. 1410880 22 6, is a selective JNK inhibitor that inhibits phosphorylation of c Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway based profiling establish the selectivity of JNK IN 8 for JNK and suggests that the compound will be broadly useful as a