SB 239063 - CAS# 193551-21-2 zone Maleate 4-dihydro-5-((5-nitro-2-thiazolyl)thio)-3H-1

4-dihydro-5-((5-nitro-2-thiazolyl)thio)-3H-1

selective and ATP-competitive mTOR inhibitor (IC50 = 2

whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM)

is an investigational drug for the acute conversion of atrial fibrillation

SB 239063 - CAS# 193551-21-2 zone Maleate 4-dihydro-5-((5-nitro-2-thiazolyl)thio)-3H-1SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin 1 and tumor necrosis factor alpha production (IC(50) values = 0. 12 and 0. 35 microM, respectively). SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Product information CAS Number: 193551 21