SKI-II - CAS# 312636-16-1 0211 4-((4-(((4-amino-2

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SKI-II - CAS# 312636-16-1 0211 4-((4-(((4-amino-2SKI II, CAS No. 312636 16 1, is a selective non lipid inhibitor of sphingosine kinase (IC50 = 0. 5 M). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI II was more efficient than two known SphK1 inhibitors SK1 I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI II was almost reversed by the general caspase inhibitor z VAD fmk. SKI II treatment inhibited

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