Loperamide Hydrochloride trihydrochloride 1 mg/kg results in efficacy

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Loperamide Hydrochloride trihydrochloride 1 mg/kg results in efficacyLoperamide Hydrochloride is an opiate agonist with selectivity for the MOR ( opiod receptor). This specificity for opioid receptors and limited penetrability into the brain prevent Loperamide from demonstrating central systemic effects generally associated with opiates. Loperamide is shown to have an effect on the Ca2+ flux through high voltage activated calcium channels in response to high levels of extracellular K+, and at higher concentrations

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