ARRY-520 (R) 30002 TH588 was dosed to the

TH588 was dosed to the mice by subcutaneous administration at 30 mg/kg once per day for 21 days

Absorption is relatively rapid in dogs but slower in mice (10 mg/kg)

PubMed PMID: 24403055

reduction of oxidative stress

ARRY-520 (R) 30002 TH588 was dosed to theARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product