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PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S CAS Number: 145821-59-6

PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S CAS Number: 145821-59-6

Name: PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S CAS Number: 145821-59-6
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PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S CAS Number: 145821-59-6PFI 1, CAS No. 1403764 72 6, is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4 with IC50 of ~98 nM and 220 nM respectively. Co crystal structures showed that PFI 1 acts as an acetyl lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD2 and BRD4. It has an EC50 of 1. 89 M for the inhibition of IL6 production from human blood mononuclear cells

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CAS Number: 145821-59-6

11(3):772-81

inhibition of cohesin release from chromosome arms

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

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