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Finally, heterogeneity in study design, included populations (often mixing children and adolescents), supplement dosages and formulations, and even comparators (sometimes active placebos such as canola oil) complicates meta-analysis and explains divergent results, especially in functional gastroenterology (132137)

By contrast, GEP44 elicited responses that were similar to those of the peptide agonist Ex-4 in assays designed to examine both internalization (Fig

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