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This provides a solid foundation for subsequent chemical modications

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Recommended monitoring approach includes: Blood pressure measurement at each clinical visit during dose titration (typically every 4 weeks) Home blood pressure monitoring for patients with known hypertension or cardiovascular disease Assessment for orthostatic hypotension (measuring BP while seated and then standing), particularly in patients taking multiple antihypertensive agents Evaluation of blood pressure trends in conjunction with weight loss trajectory Monitoring of renal function and electrolytes when adjusting diuretics or RAAS inhibitors during weight loss Patients should be educated on proper home blood pressure monitoring technique if self-monitoring is recommended