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There are two main incretin hormones in humans: GIP (glucose-dependent insulinotropic peptide

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In mice with myocardial hypertrophy induced by angiotensin II (ANGII), the expression of SLC7A11 decreased, and the inhibitory effect of SLC7A11 increased the contents of PTGS2, MDA and ROS, which aggravated cardiomyocyte hypertrophy

Keeping a detailed symptom diary and using objective markers like fecal calprotectin testing helps distinguish between medication effects and disease activity