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On the other hand, macrophages respond to various stimuli in the microenvironment and are reprogrammable into different functional subtypes after activation, usually converting in two directions: pro-inflammatory and anti-inflammatory subtypes, which are not fixed states but are mutually convertible for suitability to the changing needs and environments (59)

Am J Pharm Tech Res 2:487501 El-said KS, Hussein S, Alrashdi BM, Mahmoud HA, Ibrahim MA, Elbakry M, El-tantawy H, Kabil DI, El-naggar SA (2022) Toxicities induced by cadmium in mice